December 3, 2024 - 🧬 [nGram] Your Weekly Business Development Insights (26th Nov - 2nd Dec): Novartis & PTC Deal, Senti Bio's CAR-NK Therapy, FDA Approvals


  1. Over 50 companies are advancing 55+ therapies for Follicular Lymphoma, highlighting a robust clinical trial pipeline.
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  2. PTC Therapeutics partners with Novartis for Huntington's Disease therapy, securing $1 billion upfront and potential $1.9 billion in milestones.
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  3. Oligonucleotide Synthesis Market to grow by USD 3.37 billion by 2028, driven by RNA-based therapeutics and AI integration.
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  4. Allink Biotherapeutics raises $42M to advance bispecific antibody and ADC pipeline for oncology and immunology.
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  5. Senti Bio's SENTI-202 shows promising results in Phase 1 trial for relapsed/refractory acute myeloid leukemia.
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  6. Idorsia plans layoffs and a potential $35M licensing deal for hypertension drug Tryvio to ensure financial sustainability.
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  7. AAVantgarde Bio's AAVB-081 receives FDA Orphan Drug Designation for Usher Syndrome Type 1B Retinitis Pigmentosa.
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  8. Novartis invests $1B in PTC's Huntington Disease therapy, aiming for first disease-modifying treatment.
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  9. OraSure receives $7.5M federal funding for Marburg Virus Disease rapid antigen test development.
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  10. FDA accepts NDA resubmission for Satsuma's STS101 for acute Migraine treatment, PDUFA date set for April 2025.
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  11. Olema and Novartis collaborate on Phase 3 trial for ER+/HER2- metastatic breast cancer, securing $250M in funding.
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  12. Aidoc submits CARE1â„¢ AI model for FDA review, aiming to revolutionize CT imaging with enhanced diagnostic accuracy and efficiency.
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  13. Susanna High appointed CEO of Paragon Therapeutics, with Lee Patterson leading Metrion Biosciences.
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  14. FDA approves Mentor's MemoryGel Enhance Breast Implants for larger breast reconstruction sizes, expanding options for post-mastectomy patients.
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  15. Astorg acquires Hamilton Thorne and Cook Medical RH to form a global ART MedTech leader.
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  16. XOMA acquires Pulmokine for $20M, adding Phase 3 seralutinib for Pulmonary Arterial Hypertension to its royalty portfolio.
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  17. AI-driven growth to boost Medical Aesthetics Market by USD 18.8 billion from 2024-2028, despite high treatment costs.
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  18. JELMYTO shows a median response duration of 47.8 months in low-grade Upper Tract Urothelial Cancer patients.
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  19. FDA approves Biocon's YESINTEK, a biosimilar for Crohn's Disease, Ulcerative Colitis, Plaque Psoriasis, and Psoriatic Arthritis.
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  20. MaaT Pharma's MaaT033 shows safety and tolerability in Phase 1b trial for Amyotrophic Lateral Sclerosis.
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  21. Nemolizumab shows significant improvement in Prurigo Nodularis symptoms in Phase III trial, leading to FDA approval.
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  22. BriaCell's Phase 3 study in Metastatic Breast Cancer continues with DSMB's safety approval.
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  23. Oncolytics Biotech advances breast and pancreatic cancer trials, aiming for FDA accelerated approval.
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  24. FDA accepts Cytokinetics' NDA for aficamten to treat Obstructive Hypertrophic Cardiomyopathy, with a PDUFA date set for September 2025.
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  25. Sarepta partners with Arrowhead for siRNA programs targeting rare genetic diseases, enhancing its pipeline in muscle, CNS, and lung disorders.
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