December 3, 2024 - 🧬 [nGram] Today’s News Scoop: Jupiter Neurosciences IPO, Cartesian's Phase 2b Success, Sudo's Phase 1 Trial


  1. Jupiter neurosciences announces $11 million IPO and Nasdaq listing
    • Jupiter Neurosciences priced its IPO at $4.00 per share, offering 2,750,000 shares.
    • The company expects to raise $11 million in gross proceeds from the offering.
    • Funds will support a Phase II trial for JOTROL in Parkinson’s Disease and other strategic initiatives.
    • Shares will trade on Nasdaq under the symbol 'JUNS' starting December 3, 2024.
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  2. Cartesian Therapeutics announces positive updated results from Phase 2b trial of Descartes-08 in participants with myasthenia gravis and outlines design of planned Phase 3 trial
    • Phase 2b trial of Descartes-08 showed a 5.5-point reduction in MG-ADL at Month 4, with durable responses through Month 12.
    • Descartes-08 is an mRNA CAR-T therapy targeting BCMA, designed for outpatient administration without preconditioning chemotherapy.
    • Phase 3 AURORA trial to start in 1H2025, assessing MG-ADL improvement in 100 participants with AChR Ab+ MG.
    • Descartes-08 has RMAT and Orphan Drug Designation from the FDA for treating myasthenia gravis.
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  3. Sudo Biosciences begins phase 1 trial of brain-penetrant TYK2 inhibitor SUDO-550
    • Sudo Biosciences has dosed the first participants in a Phase 1 trial for SUDO-550, a brain-penetrant TYK2 inhibitor.
    • The trial will assess the safety, tolerability, and pharmacokinetics of SUDO-550 in healthy volunteers.
    • SUDO-550 is designed to treat neuroinflammatory diseases by effectively crossing the blood-brain barrier.
    • The company is also advancing SUDO-286, a topical TYK2 inhibitor, in two Phase 1 trials for psoriasis.
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